Taxuspinanane G from the Aerial Parts of Taxus baccata L. Growing in Iran

Abstract

Background: The discovery of paclitaxel (Taxol®) as a potent anticancer drug from Taxus brevifolia has encouraged several groups all over the world to conduct research work on other Taxus species, in order to isolate potentially more effective paclitaxel derivatives for the treatment of various cancers or as starting materials for semi-synthesis As a consequence, more than 400 taxane-type diterpenes have been isolated from various Taxus plants, and some of them were found to possess interesting anticancer activity. Objective: This study was conducted for isolation, purification and identification of taxoids occurring in the aerial parts of Taxus baccata L. from Iran. Methods: The aerial parts of the plant were extracted with organic solvent and after defatting, partitioning, column chromatography and thin layer chromatography steps, the isolated compound was identified on the basis of NMR spectrum data. Results: Taxuspinanane G was isolated and identified according to the NMR spectrum data. Conclusion: In this study, taxuspinanane G was isolated for the first time from the aerial parts of Taxus baccata L. This is the first report of the isolation of this compound from the given species.

Keywords

• taxus baccata l.
• taxuspinanane g
• taxoid
• isolation