Nature Communications (Oct 2019)
Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters
- Kaixi Zhang,
- Yu Du,
- Zhangyong Si,
- Yang Liu,
- Michelle E. Turvey,
- Cheerlavancha Raju,
- Damien Keogh,
- Lin Ruan,
- Subramanion L. Jothy,
- Sheethal Reghu,
- Kalisvar Marimuthu,
- Partha Pratim De,
- Oon Tek Ng,
- José R. Mediavilla,
- Barry N. Kreiswirth,
- Yonggui Robin Chi,
- Jinghua Ren,
- Kam C. Tam,
- Xue-Wei Liu,
- Hongwei Duan,
- Yabin Zhu,
- Yuguang Mu,
- Paula T. Hammond,
- Guillermo C. Bazan,
- Kevin Pethe,
- Mary B. Chan-Park
Affiliations
- Kaixi Zhang
- School of Chemical and Biomedical Engineering, Nanyang Technological University
- Yu Du
- School of Chemical and Biomedical Engineering, Nanyang Technological University
- Zhangyong Si
- School of Chemical and Biomedical Engineering, Nanyang Technological University
- Yang Liu
- Centre for Antimicrobial Bioengineering, Nanyang Technological University
- Michelle E. Turvey
- Infectious Disease Interdisciplinary Research Group, Singapore-MIT Alliance for Research & Technology Centre
- Cheerlavancha Raju
- School of Chemical and Biomedical Engineering, Nanyang Technological University
- Damien Keogh
- School of Chemical and Biomedical Engineering, Nanyang Technological University
- Lin Ruan
- School of Chemical and Biomedical Engineering, Nanyang Technological University
- Subramanion L. Jothy
- School of Chemical and Biomedical Engineering, Nanyang Technological University
- Sheethal Reghu
- School of Chemical and Biomedical Engineering, Nanyang Technological University
- Kalisvar Marimuthu
- Department of Infectious Diseases, Tan Tock Seng Hospital
- Partha Pratim De
- Department of Laboratory Medicine, Tan Tock Seng Hospital
- Oon Tek Ng
- Department of Infectious Diseases, Tan Tock Seng Hospital
- José R. Mediavilla
- Center for Discovery and Innovation, Hackensack Meridian Health
- Barry N. Kreiswirth
- Center for Discovery and Innovation, Hackensack Meridian Health
- Yonggui Robin Chi
- Division of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University
- Jinghua Ren
- Cancer Center, Union Hospital, Huazhong University of Science & Technology
- Kam C. Tam
- Department of Chemical Engineering, Waterloo Institute for Nanotechnology, University of Waterloo
- Xue-Wei Liu
- Centre for Antimicrobial Bioengineering, Nanyang Technological University
- Hongwei Duan
- School of Chemical and Biomedical Engineering, Nanyang Technological University
- Yabin Zhu
- Medical School of Ningbo University, Ningbo
- Yuguang Mu
- School of Biological Sciences, Nanyang Technological University
- Paula T. Hammond
- Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Guillermo C. Bazan
- Department of Chemistry and Biochemistry, University of California Santa Barbara
- Kevin Pethe
- Centre for Antimicrobial Bioengineering, Nanyang Technological University
- Mary B. Chan-Park
- School of Chemical and Biomedical Engineering, Nanyang Technological University
- DOI
- https://doi.org/10.1038/s41467-019-12702-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
The authors report the synthesis of an enantiomeric block co-beta-peptide that kills methicillin-resistant Staphylococcus aureus, including biofilm and persister bacterial cells, and disperses biofilms. The copolymer displays antibacterial activity in human ex vivo and mouse in vivo infection models without toxicity.
