Cooperative assembly of p97 complexes involved in replication termination

Olga V. Kochenova; Sirisha Mukkavalli; Malavika Raman; Johannes C. Walter

doi:10.1038/s41467-022-34210-y

Nature Communications (Nov 2022)

Cooperative assembly of p97 complexes involved in replication termination

Olga V. Kochenova,
Sirisha Mukkavalli,
Malavika Raman,
Johannes C. Walter

Affiliations

Olga V. Kochenova: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute
Sirisha Mukkavalli: Department of Developmental Molecular and Chemical Biology, Tufts University School of Medicine
Malavika Raman: Department of Developmental Molecular and Chemical Biology, Tufts University School of Medicine
Johannes C. Walter: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute

DOI: https://doi.org/10.1038/s41467-022-34210-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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This study describes how p97Ufd1-Npl4 and the UBA-UBX protein Ubxn7 disassemble vertebrate replisomes during replication termination, and it provides novel insights into how p97 complexes assemble with UBA-UBX proteins on ubiquitylated substrates

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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