Mechanisms of regulation of erythrocytes volume in cardiosurgical patients with moderated and expressed the hemolysis after operations

Abstract

A study of mechanisms of regulation of volume of erythrocytes in cardiosurgical patients with moderate (24 patients) and expressed (13 patients) hemolysis after coronary artery bypass grafting in conditions of cardiopulmonary bypass was carried out. It was established that development expressed hemolysis is associated with higher (than under moderate hemolysis) volume of erythrocytes after operation, reduction Са2+-dependent К+-permeability and activity of Nа+/K+-ATPazy in their against deficiency of ATP in cells. At patients with moderated hemolysis independently of an investigation phase Са2+-dependent К+-permeability of a membrane of erythrocytes doesn't differ from healthy donors, but activity of Nа+/K+-ATPazy is reduced at the sufficient content of ATP.

Keywords

• гемолиз
• объем эритроцита, са2+-зависимая к+-проницаемость
• nа+/k+-atфаза
• атф
• искусственное кровообращение