Clinical Epidemiology (May 2023)

Cancer and Mortality Risks of Graves’ Disease in South Korea Based on National Data from 2010 to 2019

  • Choi YJ,
  • Han K,
  • Cho WK,
  • Jung MH,
  • Suh BK

Journal volume & issue
Vol. Volume 15
pp. 535 – 546

Abstract

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Young Ju Choi,1 Kyungdo Han,2 Won Kyoung Cho,3 Min Ho Jung,1 Byung-Kyu Suh4 1Department of Pediatrics, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; 2Department of Statistics and Actuarial Science, College of Natural Sciences, Soongsil University, Seoul, Republic of Korea; 3Department of Pediatrics, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; 4Department of Pediatrics, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaCorrespondence: Won Kyoung Cho, Department of Pediatrics, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, 93, Jungbu-daero, Paldal-gu, Suwon-si, Gyeonggi-do, 16247, Republic of Korea, Tel +82-31-249-8869, Fax +82-2-783-2589, Email [email protected]: This study aimed to investigate Graves’ disease (GD) associated cancer and mortality risk using a Korean population-based study.Patients and Methods: We included 6435 patients with GD using the Korean National Health Insurance Service–National Sample Cohort database from 2010 to 2019. Data concerning such patients were compared in a 1:5 ratio with age- and sex-matched non-GD group (n=32,175). Eighteen subdivided types of cancer and cancers-in-total were analyzed. In addition to the mortality analysis, subgroup analyses were performed according to age and sex.Results: After adjustment, the hazard ratio (HR) of the GD group for cancer-in-total was 1.07 (95% confidence interval [CI], 0.91– 1.27), showing no difference when compared to the non-GD group. However, among different types of cancer, the thyroid cancer risk of the GD group was higher than that of the non-GD group (HR=1.70; 95% CI, 1.20– 2.39). When subdivided by age and sex, the thyroid cancer risk of the GD group in males aged 20– 39 years was higher than that of the non-GD group (HR=7.00; 95% CI, 1.48– 33.12). The mortality risk of the GD group was not different from that of the non-GD group (HR=0.86; 95% CI, 0.70– 1.05).Conclusion: In South Korea, patients with GD had a higher risk of thyroid cancer than the non-GD group. In particular, males aged 20– 39 years with GD were more likely to have thyroid cancer than the non-GD group.Keywords: Graves disease, neoplasms, mortality, Republic of Korea

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