Hollow porous PLA/PBAT composite microfibers with enhanced toughness and prolonged drug release for wound healing

Yufei Liu; Yuanzhi Wei; Qinqin Xiong; Chuan Xie; Taofang An; Min He; Lu Xia; Shinan Wei; Jia Yu; Sha Cheng; Bixue Xu; Mashaal Ahmad; Xi Zeng; Jie Yu; Sihai Luo; Heng Luo

Materials & Design (Jan 2024)

Hollow porous PLA/PBAT composite microfibers with enhanced toughness and prolonged drug release for wound healing

Yufei Liu,
Yuanzhi Wei,
Qinqin Xiong,
Chuan Xie,
Taofang An,
Min He,
Lu Xia,
Shinan Wei,
Jia Yu,
Sha Cheng,
Bixue Xu,
Mashaal Ahmad,
Xi Zeng,
Jie Yu,
Sihai Luo,
Heng Luo

Affiliations

Yufei Liu: Department of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China; National Engineering Research Center for Compounding and Modification of Polymeric Materials, Guiyang 550014, China
Yuanzhi Wei: Department of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China; Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025, China
Qinqin Xiong: State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China
Chuan Xie: Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China; Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025, China
Taofang An: Department of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China
Min He: Department of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China; National Engineering Research Center for Compounding and Modification of Polymeric Materials, Guiyang 550014, China
Lu Xia: Department of Chemistry, Norwegian University of Science and Technology (NTNU), Trondheim 7491, Norway
Shinan Wei: State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China
Jia Yu: State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China
Sha Cheng: State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China
Bixue Xu: State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China
Mashaal Ahmad: State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China
Xi Zeng: Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang 550025, China
Jie Yu: Department of Polymer Material and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China; National Engineering Research Center for Compounding and Modification of Polymeric Materials, Guiyang 550014, China
Sihai Luo: Department of Chemistry, Norwegian University of Science and Technology (NTNU), Trondheim 7491, Norway; Corresponding authors at: State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China (H. Luo).
Heng Luo: State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, China; Corresponding authors at: State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China (H. Luo).

Journal volume & issue: Vol. 237
p. 112624

Abstract

Read online

An appropriate wound dressing is necessary to enhance the recovery of wounds and the restoration of tissue after the skin gets injured. In this study, a hollow porous microfiber (HPMF) scaffold composed of a combination of polylactic acid (PLA)/polybutylene adipate/butylene terephthalate (PBAT)/polyvinyl alcohol (PVA) was developed using coaxial electrospinning for wound healing. The porous structure of PLA/PBAT HPMFs was formed by dissolving PVA in water. The results showed that when maintaining a PLA: PBAT weight ratio of 7:3, high-quality porous PLA/PBAT composites were achieved, leading to a 36.25% increase in toughness and a 4.9% increase in biodegradability compared to pure PLA. Furthermore, in vivo wound healing assays suggest that composites successfully loaded can effectively promote wound healing on the 13th day. Therefore, this work underscores the significant potential of PLA/PBAT HPMF dressing for wound repair.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

About the journal

Abstract

Keywords