Insufficient Pulmonary Rehabilitation Uptake After Severe Exacerbation of COPD: A Multicentre Study in the South West Region of France

Abstract

Marina Gueçamburu,1– 3 Guillaume Verdy,4 Julie Cuadros,1 Cécilia Nocent-Ejnaini,2 Julie Macey,1 Laurent Portel,3 Amandine Rapin,5,6 Maéva Zysman1,7 1Service des Maladies Respiratoires, CHU Bordeaux, Pessac, 33604, France; 2Service de pneumologie, Centre Hospitalier de la Côte Basque, Bayonne, France; 3Service de pneumologie, Centre Hospitalier Robert Boulin, Libourne, France; 4Unité d’Informatique et d’Archivistique Médicales, Service d’Information Médicale, CHU Bordeaux, Pessac, 33604, France; 5Université de Reims Champagne-Ardenne, VieFra, Reims, F-51100, France; 6CHU de Reims, Unité de Médecine Physique et de Réadaptation, Reims, F-51100, France; 7Univ-Bordeaux, Centre de Recherche cardio-thoracique de Bordeaux, U1045, CIC 1401, Pessac, F-33604, FranceCorrespondence: Marina Gueçamburu, Service des Maladies Respiratoires, CHU Bordeaux, Pessac, 33604, France, Email [email protected]: Pulmonary rehabilitation (PR) is a type of multidisciplinary care strongly recommended after severe exacerbation of chronic obstructive pulmonary disease (COPD). Recently, a national French study reported a very low rate of PR uptake (8.6%); however, important clinical data were missing. Here, we aimed to identify the main factors associated with insufficient PR uptake after hospitalisation for COPD exacerbation.Patients and Methods: This multicentre retrospective study included patients hospitalised with COPD exacerbation between 1 January 2017 and 31 December 2018, as identified by both coding and a detailed review of medical records. PR was defined as inpatient care in a specialised centre or unit within 90 days of discharge. Multivariate logistic regression was used to identify associations between PR uptake and patient characteristics, such as comorbidities, non-invasive ventilation (NIV), inhaled treatment, and forced expiratory volume in 1 second (FEV1).Results: Among the 325 patients admitted for severe COPD exacerbation, 92 (28.3%) underwent PR within 90 days of discharge. In univariate analysis, relative to those who underwent PR, patients without PR had significantly more comorbidities, were less often treated with triple bronchodilator therapy or NIV, and had a higher FEV1. In multivariate analysis, variables independently associated with the lack of PR uptake were the presence of comorbidities (adjusted odds ratio (aOR) = 1.28 [1.10– 1.53], p = 0.003) and a higher FEV1 (aOR = 1.04 [1.02– 1.06], p < 0.001). There was no significant correlation between PR uptake and departmental PR centre capacity (notably, some departments had no PR facilities).Conclusion: These data highlight the lack of PR in the early stages of COPD. Collaboration among all healthcare providers involved in patient management is crucial for improved PR uptake.Plain Language Summary: Pulmonary rehabilitation (PR) is multidisciplinary care strongly recommended after severe exacerbation of chronic obstructive pulmonary disease (COPD); however, referral remains very low in France. We have shown, in three French centres, that early-stage COPD and associated comorbidities are the main factors contributing to insufficient PR after hospitalisation for exacerbation. Collaboration among all healthcare providers involved in patient management is crucial to improve PR uptake in the years ahead because physical medicine and rehabilitation professionals play key roles in the promotion and early initiation of PR programs.Keywords: COPD, comorbidities, healthcare resources, pulmonary rehabilitation

Keywords

• copd
• comorbidities
• healthcare resources
• pulmonary rehabilitation