Bacillus coagulans-associated severe necrotizing scleral infection

Abstract

Purpose: We describe a case of severe scleritis possibly caused by Bacillus coagulans. Observations: Conventional laboratory evaluation was inconclusive. The associated organism was identified with metagenomic RNA deep sequencing (MDS). The infection resolved with trimethoprim-sulfamethoxazole treatment. Conclusions: This case demonstrates the utility of unbiased, high-throughput sequencing for infectious scleritis.

Keywords

• Next generation sequencing
• Uveitis
• Sclerokeratitis
• bacillus
• Fastidious organism