Nature Communications (Feb 2021)
The acquisition of molecular drivers in pediatric therapy-related myeloid neoplasms
- Jason R. Schwartz,
- Jing Ma,
- Jennifer Kamens,
- Tamara Westover,
- Michael P. Walsh,
- Samuel W. Brady,
- J. Robert Michael,
- Xiaolong Chen,
- Lindsey Montefiori,
- Guangchun Song,
- Gang Wu,
- Huiyun Wu,
- Cristyn Branstetter,
- Ryan Hiltenbrand,
- Michael F. Walsh,
- Kim E. Nichols,
- Jamie L. Maciaszek,
- Yanling Liu,
- Priyadarshini Kumar,
- John Easton,
- Scott Newman,
- Jeffrey E. Rubnitz,
- Charles G. Mullighan,
- Stanley Pounds,
- Jinghui Zhang,
- Tanja Gruber,
- Xiaotu Ma,
- Jeffery M. Klco
Affiliations
- Jason R. Schwartz
- Vanderbilt University Medical Center, Department of Pediatrics
- Jing Ma
- St. Jude Children’s Research Hospital, Department of Pathology
- Jennifer Kamens
- Stanford University School of Medicine, Department of Pediatrics
- Tamara Westover
- St. Jude Children’s Research Hospital, Department of Pathology
- Michael P. Walsh
- St. Jude Children’s Research Hospital, Department of Pathology
- Samuel W. Brady
- St. Jude Children’s Research Hospital, Department of Computational Biology
- J. Robert Michael
- St. Jude Children’s Research Hospital, Department of Computational Biology
- Xiaolong Chen
- St. Jude Children’s Research Hospital, Department of Computational Biology
- Lindsey Montefiori
- St. Jude Children’s Research Hospital, Department of Pathology
- Guangchun Song
- St. Jude Children’s Research Hospital, Department of Pathology
- Gang Wu
- St. Jude Children’s Research Hospital, Department of Computational Biology
- Huiyun Wu
- St. Jude Children’s Research Hospital, Department of Biostatistics
- Cristyn Branstetter
- Arkansas Children’s Northwest Hospital, Department of Hematology/Oncology
- Ryan Hiltenbrand
- St. Jude Children’s Research Hospital, Department of Pathology
- Michael F. Walsh
- Memorial Sloan Kettering Cancer Center, Department of Pediatrics
- Kim E. Nichols
- St. Jude Children’s Research Hospital, Department of Oncology
- Jamie L. Maciaszek
- St. Jude Children’s Research Hospital, Department of Oncology
- Yanling Liu
- St. Jude Children’s Research Hospital, Department of Computational Biology
- Priyadarshini Kumar
- St. Jude Children’s Research Hospital, Department of Pathology
- John Easton
- St. Jude Children’s Research Hospital, Department of Computational Biology
- Scott Newman
- St. Jude Children’s Research Hospital, Department of Computational Biology
- Jeffrey E. Rubnitz
- St. Jude Children’s Research Hospital, Department of Oncology
- Charles G. Mullighan
- St. Jude Children’s Research Hospital, Department of Pathology
- Stanley Pounds
- St. Jude Children’s Research Hospital, Department of Biostatistics
- Jinghui Zhang
- St. Jude Children’s Research Hospital, Department of Computational Biology
- Tanja Gruber
- Stanford University School of Medicine, Department of Pediatrics
- Xiaotu Ma
- St. Jude Children’s Research Hospital, Department of Computational Biology
- Jeffery M. Klco
- St. Jude Children’s Research Hospital, Department of Pathology
- DOI
- https://doi.org/10.1038/s41467-021-21255-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Paediatric therapy-related myeloid neoplasms (tMN) have a dismal prognosis and have not been comprehensively profiled. Here the authors characterise the molecular landscape of 84 paediatric tMN patients, and find that, unlike adult tMNs, these do not emerge from pre-existing clones and that MECOM dysregulation is frequent.
