Inflammation and immune activation are associated with risk of Mycobacterium tuberculosis infection in BCG-vaccinated infants

Iman Satti; Rachel E. Wittenberg; Shuailin Li; Stephanie A. Harris; Rachel Tanner; Deniz Cizmeci; Ashley Jacobs; Nicola Williams; Humphrey Mulenga; Helen A. Fletcher; Thomas J. Scriba; Michele Tameris; Mark Hatherill; Helen McShane

doi:10.1038/s41467-022-34061-7

Nature Communications (Nov 2022)

Inflammation and immune activation are associated with risk of Mycobacterium tuberculosis infection in BCG-vaccinated infants

Iman Satti,
Rachel E. Wittenberg,
Shuailin Li,
Stephanie A. Harris,
Rachel Tanner,
Deniz Cizmeci,
Ashley Jacobs,
Nicola Williams,
Humphrey Mulenga,
Helen A. Fletcher,
Thomas J. Scriba,
Michele Tameris,
Mark Hatherill,
Helen McShane

Affiliations

Iman Satti: Jenner Institute, Nuffield Department of Medicine, University of Oxford
Rachel E. Wittenberg: Jenner Institute, Nuffield Department of Medicine, University of Oxford
Shuailin Li: Jenner Institute, Nuffield Department of Medicine, University of Oxford
Stephanie A. Harris: Jenner Institute, Nuffield Department of Medicine, University of Oxford
Rachel Tanner: Jenner Institute, Nuffield Department of Medicine, University of Oxford
Deniz Cizmeci: Jenner Institute, Nuffield Department of Medicine, University of Oxford
Ashley Jacobs: Jenner Institute, Nuffield Department of Medicine, University of Oxford
Nicola Williams: Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter
Humphrey Mulenga: South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town
Helen A. Fletcher: Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine
Thomas J. Scriba: South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town
Michele Tameris: South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town
Mark Hatherill: South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town
Helen McShane: Jenner Institute, Nuffield Department of Medicine, University of Oxford

DOI: https://doi.org/10.1038/s41467-022-34061-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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The identification of immune correlates of protection in humans would inform on the design and development of tuberculosis vaccine candidates. In this work, authors examine samples collected from South African infants, to determine whether the correlates of risk of tuberculosis disease, previously identified in this population, are also correlates of risk of M. tuberculosis infection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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