Correlation of prognostic factors with MRI findings in malignant breast lesions

Abstract

Abstract Background Magnetic resonance imaging (MRI) of the breast represents the most sensitive imaging modality in the detection of breast cancer, with a reported sensitivity between 94 and 100%. We aim to detect the correlation between MRI findings and pathologically detected prognostic factors in malignant breast lesions. Breast parenchymal density distribution, background parenchymal enhancement pattern, lesion’s morphologic features, T2WI signal characteristics, contrast enhancement, time/signal intensity curves, and lesions localizations in breast were evaluated using dynamic MRI images. Histopathological diagnosis, maximum measurements of the lesion, histological grade, presence of estrogen and/or progesterone receptors, c-erb B2, and Ki-67 parameters were noted as prognostic factors. Results We cannot detect any relationship between the breast parenchymal density and prognostic factors. Mild background breast enhancement is related with ER presence, a good prognostic factor. Histopathological grade of the lesions augmented with the increase in the lesion diameters. ADC values are not related with prognostic factors. Conclusion A mild background enhancement, an intermediate signal intensity on T2WI, a high tpeak value, and absence of pathological axillary lymph node are found to be related with good prognostic factors. An irregular contour, a huge diameter, having a type III kinetic curve, a high slopei value, and presence of pathological axillary lymph node are found to be related with poor prognostic factors. MRI can be used to predict prognostic factors in breast cancer cases.

Keywords

• Breast
• Malignancy
• Prognostic factor
• MRI