Potential of Fibrin Glue and Mesenchymal Stem Cells (MSCs) to Regenerate Nerve Injuries: A Systematic Review
Adriana de Cássia Ortiz,
Simone Ortiz Moura Fideles,
Karina Torres Pomini,
Márcia Zilioli Bellini,
Eliana de Souza Bastos Mazuqueli Pereira,
Carlos Henrique Bertoni Reis,
João Paulo Galletti Pilon,
Miguel Ângelo de Marchi,
Beatriz Flavia de Moraes Trazzi,
Willian Saranholi da Silva,
Marcelo Rodrigues da Cunha,
Daniela Vieira Buchaim,
Rogerio Leone Buchaim
Affiliations
Adriana de Cássia Ortiz
Department of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, Brazil
Simone Ortiz Moura Fideles
Department of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, Brazil
Karina Torres Pomini
Department of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, Brazil
Márcia Zilioli Bellini
Pro-Rectory of Research and Graduate Studies, University Center of Adamantina (UniFAI), Adamantina 17800-000, Brazil
Eliana de Souza Bastos Mazuqueli Pereira
Postgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marilia (UNIMAR), Marília 17525-902, Brazil
Carlos Henrique Bertoni Reis
Department of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, Brazil
João Paulo Galletti Pilon
UNIMAR Beneficent Hospital (HBU), Medical School, University of Marilia (UNIMAR), Marília 17525-160, Brazil
Miguel Ângelo de Marchi
Coordination of the Medical School, University Center of Adamantina (UniFAI), Adamantina 17800-000, Brazil
Beatriz Flavia de Moraes Trazzi
Coordination of the Dentistry School, University of Marilia (UNIMAR), Marília 17525-902, Brazil
Willian Saranholi da Silva
Dentistry School, University of Marilia (UNIMAR), Marília 17525-902, Brazil
Marcelo Rodrigues da Cunha
Interunit Postgraduate Program in Bioengineering (EESC/FMRP/IQSC), University of São Paulo (USP), São Carlos 13566-590, Brazil
Daniela Vieira Buchaim
Postgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marilia (UNIMAR), Marília 17525-902, Brazil
Rogerio Leone Buchaim
Department of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, Brazil
Cell-based therapy is a promising treatment to favor tissue healing through less invasive strategies. Mesenchymal stem cells (MSCs) highlighted as potential candidates due to their angiogenic, anti-apoptotic and immunomodulatory properties, in addition to their ability to differentiate into several specialized cell lines. Cells can be carried through a biological delivery system, such as fibrin glue, which acts as a temporary matrix that favors cell-matrix interactions and allows local and paracrine functions of MSCs. Thus, the aim of this systematic review was to evaluate the potential of fibrin glue combined with MSCs in nerve regeneration. The bibliographic search was performed in the PubMed/MEDLINE, Web of Science and Embase databases, using the descriptors (“fibrin sealant” OR “fibrin glue”) AND “stem cells” AND “nerve regeneration”, considering articles published until 2021. To compose this review, 13 in vivo studies were selected, according to the eligibility criteria. MSCs favored axonal regeneration, remyelination of nerve fibers, as well as promoted an increase in the number of myelinated fibers, myelin sheath thickness, number of axons and expression of growth factors, with significant improvement in motor function recovery. This systematic review showed clear evidence that fibrin glue combined with MSCs has the potential to regenerate nervous system lesions.
