Synthesis of Conformationally Constrained Aryl- or Heteroarylpiperazinyl Derivatives of Selected Imides as 5-HT1A Receptor Ligands

Abstract

The preparation of a number of cyclic imide 5-HT1A receptor ligandderivatives has been described. Their structures were conformationally constrained byintroducing rigid linkers containing unsaturated bonds or aromatic benzene rings. Thesecompounds are expected to possess anxiolytic and antidepressant activity.

Keywords

• Conformational constraints
• cis- and trans-2-butene derivatives
• 1
• 2- bismethylbenzene derivatives
• imides
• 5-HT1A receptor ligands.