Nature Communications (Dec 2022)
Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity
- Caitriona M. McEvoy,
- Julia M. Murphy,
- Lin Zhang,
- Sergi Clotet-Freixas,
- Jessica A. Mathews,
- James An,
- Mehran Karimzadeh,
- Delaram Pouyabahar,
- Shenghui Su,
- Olga Zaslaver,
- Hannes Röst,
- Rangi Arambewela,
- Lewis Y. Liu,
- Sally Zhang,
- Keith A. Lawson,
- Antonio Finelli,
- Bo Wang,
- Sonya A. MacParland,
- Gary D. Bader,
- Ana Konvalinka,
- Sarah Q. Crome
Affiliations
- Caitriona M. McEvoy
- Toronto General Hospital Research Institute, University Health Network
- Julia M. Murphy
- Toronto General Hospital Research Institute, University Health Network
- Lin Zhang
- Department of Statistical Sciences, University of Toronto
- Sergi Clotet-Freixas
- Toronto General Hospital Research Institute, University Health Network
- Jessica A. Mathews
- Toronto General Hospital Research Institute, University Health Network
- James An
- Toronto General Hospital Research Institute, University Health Network
- Mehran Karimzadeh
- Peter Munk Cardiac Centre, University Health Network
- Delaram Pouyabahar
- Department of Molecular Genetics, University of Toronto
- Shenghui Su
- Toronto General Hospital Research Institute, University Health Network
- Olga Zaslaver
- Department of Molecular Genetics, University of Toronto
- Hannes Röst
- Department of Molecular Genetics, University of Toronto
- Rangi Arambewela
- Toronto General Hospital Research Institute, University Health Network
- Lewis Y. Liu
- Toronto General Hospital Research Institute, University Health Network
- Sally Zhang
- Division of Urology, Princess Margaret Cancer Centre, University Health Network
- Keith A. Lawson
- Division of Urology, Princess Margaret Cancer Centre, University Health Network
- Antonio Finelli
- Division of Urology, Princess Margaret Cancer Centre, University Health Network
- Bo Wang
- Peter Munk Cardiac Centre, University Health Network
- Sonya A. MacParland
- Toronto General Hospital Research Institute, University Health Network
- Gary D. Bader
- Department of Molecular Genetics, University of Toronto
- Ana Konvalinka
- Toronto General Hospital Research Institute, University Health Network
- Sarah Q. Crome
- Toronto General Hospital Research Institute, University Health Network
- DOI
- https://doi.org/10.1038/s41467-022-35297-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Knowledge of the transcriptional programs of human kidney cell populations at homeostasis is limited. Here, the authors show sex-based differences in gene expression of kidney parenchymal cells and examine the complexity of kidney-resident immune cells using single cell RNA sequencing of healthy living kidney donors.
