Communications Biology (Jan 2023)
The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells
- Christopher Noyes,
- Shunsuke Kitajima,
- Fengkai Li,
- Yusuke Suita,
- Saradha Miriyala,
- Shakson Isaac,
- Nagib Ahsan,
- Erik Knelson,
- Amir Vajdi,
- Tetsuo Tani,
- Tran C. Thai,
- Derek Xu,
- Junko Murai,
- Nikos Tapinos,
- Chiaki Takahashi,
- David A. Barbie,
- Mamiko Yajima
Affiliations
- Christopher Noyes
- Department of Molecular Biology Cell Biology Biochemistry, Brown University
- Shunsuke Kitajima
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Fengkai Li
- Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University
- Yusuke Suita
- Laboratory of Cancer Epigenetics and Plasticity, Department of Neurosurgery, Brown University
- Saradha Miriyala
- Laboratory of Cancer Epigenetics and Plasticity, Department of Neurosurgery, Brown University
- Shakson Isaac
- Department of Molecular Biology Cell Biology Biochemistry, Brown University
- Nagib Ahsan
- Department of Chemistry and Biochemistry, The University of Oklahoma
- Erik Knelson
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Amir Vajdi
- Department of Informatics and Analytics, Dana-Farber Cancer Institute
- Tetsuo Tani
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Tran C. Thai
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Derek Xu
- Department of Molecular Biology Cell Biology Biochemistry, Brown University
- Junko Murai
- Institute for Advanced Biosciences, Keio University
- Nikos Tapinos
- Laboratory of Cancer Epigenetics and Plasticity, Department of Neurosurgery, Brown University
- Chiaki Takahashi
- Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University
- David A. Barbie
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Mamiko Yajima
- Department of Molecular Biology Cell Biology Biochemistry, Brown University
- DOI
- https://doi.org/10.1038/s42003-023-04444-7
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 14
Abstract
DDX4, a conserved germline factor and RNA helicase, increases small cell lung cancer cell survival by regulating DNA damage and immune response pathways and contributes to cisplatin-mediated drug resistance.
