Abstract High‐performance self‐powered pressure sensors have attracted much attention due to their potential applications in bionic limbs, healthy motion detection, medical devices, and other fields. However, existing devices are either imperceptible to the pressure direction or require an external power source as a driving force. Here, a pressure sensor inspired by the structure of serosal membranes is reported, which contains a novel partially reduced graphene oxide (prGO) membrane. In this Serosa‐Mimetic structured membrane, a narrow “Trail” structure containing COOH is considered as an ion filter and ion conductor, which facilitates the directional migration of cations under external stimuli, resulting in a directional flow of net charges, resulting in current (or voltage) signal. Therefore, the prGO‐Trail membrane can be used as an ion transport layer to facilitate self‐powered pressure sensing. This pressure‐driven output voltage (and current), produced by ion selectivity, is linear with the applied pressure. The fabricated self‐powered bionic pressure sensor has good performance, the optimized response sensitivity is 0.282 nA Pa−1, the response/recovery time is 90/110 ms, and long‐term stability (1000 cycles), which provides a meaningful design idea and a larger open field of vision for the next generation of self‐driving bionic pressure sensors.
