Molecular & Cellular Oncology (Jan 2019)

Oncogenic β-catenin mutations evade pH-regulated degradation

  • Bree K. Grillo-Hill,
  • Katharine A. White

DOI
https://doi.org/10.1080/23723556.2018.1554470
Journal volume & issue
Vol. 6, no. 1

Abstract

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β-catenin has roles in cell-cell adhesion and Wnt signaling. We recently showed that β-catenin protein abundance is decreased at higher intracellular pH (pHi), mediated by pH-sensitive interaction with the beta-transducin repeat containing E3 ubiquitin protein ligase (β-TrCP). Increased pHi facilitates β-TrCP binding and degradation of β-catenin. β-catenin mutations that abrogate the pH-sensitive interaction induce significant tumors not seen with other β-catenin stabilizing mutants.

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