Nature Communications (Oct 2016)

Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer

  • Steffen Grampp,
  • James L. Platt,
  • Victoria Lauer,
  • Rafik Salama,
  • Franziska Kranz,
  • Viviana K. Neumann,
  • Sven Wach,
  • Christine Stöhr,
  • Arndt Hartmann,
  • Kai-Uwe Eckardt,
  • Peter J. Ratcliffe,
  • David R. Mole,
  • Johannes Schödel

DOI
https://doi.org/10.1038/ncomms13183
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 11

Abstract

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Genome-wide association studies have identified multiple loci associated with the risk of developing renal cancer. Here, the authors show that one of these loci generates open chromatin, which enhances the binding of HIF and HIF-mediated transactivation ofMYC.