Frontiers in Pediatrics (Jul 2021)
Supportive Care During Pediatric Hematopoietic Stem Cell Transplantation: Prevention of Infections. A Report From Workshops on Supportive Care of the Paediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT)
- Marianne Ifversen,
- Roland Meisel,
- Petr Sedlacek,
- Krzysztof Kalwak,
- Luisa Sisinni,
- Daphna Hutt,
- Thomas Lehrnbecher,
- Adriana Balduzzi,
- Tamara Diesch,
- Andrea Jarisch,
- Tayfun Güngör,
- Jerry Stein,
- Isaac Yaniv,
- Halvard Bonig,
- Michaela Kuhlen,
- Marc Ansari,
- Marc Ansari,
- Tiago Nava,
- Tiago Nava,
- Jean-Hugues Dalle,
- Cristina Diaz-de-Heredia,
- Eugenia Trigoso,
- Ulrike Falkenberg,
- Mihaela Hartmann,
- Marco Deiana,
- Marta Canesi,
- Chiara Broggi,
- Alice Bertaina,
- Alice Bertaina,
- Brenda Gibson,
- Gergely Krivan,
- Kim Vettenranta,
- Toni Matic,
- Jochen Buechner,
- Anita Lawitschka,
- Christina Peters,
- Akif Yesilipek,
- Koray Yalçin,
- Giovanna Lucchini,
- Shahrzad Bakhtiar,
- Dominik Turkiewicz,
- Riitta Niinimäki,
- Jacek Wachowiak,
- Simone Cesaro,
- Arnaud Dalissier,
- Selim Corbacioglu,
- Andre Manfred Willasch,
- Peter Bader
Affiliations
- Marianne Ifversen
- Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
- Roland Meisel
- Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany
- Petr Sedlacek
- Department of Pediatric Hematology and Oncology, Hospital Motol, Charles University, Prague, Czechia
- Krzysztof Kalwak
- Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland
- Luisa Sisinni
- Pediatric Hematology, Oncology and Hematopoietic Stem Cell Transplantation Unit, Hospital Santa Creu i Sant Pau, Barcelona, Spain
- Daphna Hutt
- Division of Pediatric Hematology, Oncology and Bone Marrow Transplantation, The Edmond and Lily Safra Children's Hospital, Tel Aviv, Israel
- Thomas Lehrnbecher
- Division for Pediatric Hematology and Oncology, Hospital for Children and Adolescents, University Hospital, Goethe University, Frankfurt am Main, Germany
- Adriana Balduzzi
- Clinica Pediatrica Università degli Studi di Milano Bicocca, Fondazione Monza e Brianza per il Bambino e la sua Mamma, Ospedale San Gerardo, Monza, Italy
- Tamara Diesch
- Division of Pediatric Hematology-Oncology, University Children's Hospital of Basel, Basel, Switzerland
- Andrea Jarisch
- 0Division for Stem Cell Transplantation, Immunology and Intensive Care Medicine, Hospital for Children and Adolescents, University Hospital, Goethe University, Frankfurt am Main, Germany
- Tayfun Güngör
- 1Department of Hematology, Immunology, Oncology and Stem Cell Transplantation, University Children's Hospital Zürich, Zurich, Switzerland
- Jerry Stein
- 2Division of Pediatric Hematoloy-Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel
- Isaac Yaniv
- 2Division of Pediatric Hematoloy-Oncology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel
- Halvard Bonig
- 3Institute for Transfusion Medicine and Immunohematology of Goethe University, German Red Cross Blood Service Baden-Württemberg-Hessen, Frankfurt am Main, Germany
- Michaela Kuhlen
- 4Paediatrics and Adolescent Medicine, Medical Faculty, University of Augsburg, Augsburg, Germany
- Marc Ansari
- 5Division of Pediatric Hematology-Oncology, University Hospital of Geneva, Geneva, Switzerland
- Marc Ansari
- 6Cansearch Research Platform in Paediatric Oncology and Haematology, Department of Paediatrics, Gynaecology and Obstetrics, Faculty of Medicine, University of Geneva, Geneva, Switzerland
- Tiago Nava
- 5Division of Pediatric Hematology-Oncology, University Hospital of Geneva, Geneva, Switzerland
- Tiago Nava
- 6Cansearch Research Platform in Paediatric Oncology and Haematology, Department of Paediatrics, Gynaecology and Obstetrics, Faculty of Medicine, University of Geneva, Geneva, Switzerland
- Jean-Hugues Dalle
- 7Hematology and Immunology Department, Robert-Debre Hospital, Assistance Publique-Hopitaux de Paris and University of Paris, Paris, France
- Cristina Diaz-de-Heredia
- 8Department of Pediatric Oncology and Hematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain
- Eugenia Trigoso
- 9Paediatric Transplant Unit, Hospital University and Polytechnic, Hospital LA FE, Valencia, Spain
- Ulrike Falkenberg
- 0Stem Cell Transplantation-Unit, Department of Pediatrics, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria
- Mihaela Hartmann
- 0Stem Cell Transplantation-Unit, Department of Pediatrics, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria
- Marco Deiana
- 1Paediatric Haematology-Oncology Department, Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini, Genova, Italy
- Marta Canesi
- Clinica Pediatrica Università degli Studi di Milano Bicocca, Fondazione Monza e Brianza per il Bambino e la sua Mamma, Ospedale San Gerardo, Monza, Italy
- Chiara Broggi
- Clinica Pediatrica Università degli Studi di Milano Bicocca, Fondazione Monza e Brianza per il Bambino e la sua Mamma, Ospedale San Gerardo, Monza, Italy
- Alice Bertaina
- 2Department of Pediatric Hematology-Oncology and Cell and Gene Therapy, Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Bambino Gesù, Rome, Italy
- Alice Bertaina
- 3Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA, United States
- Brenda Gibson
- 4Department of Paediatric Haematology–Oncology, Royal Hospital for Children, Glasgow, United Kingdom
- Gergely Krivan
- 5Central Hospital of Southern Pest, National Institute of Hematology and Infectious Disease, Budapest, Hungary
- Kim Vettenranta
- 6Children's Hospital and Pediatric Research Center, University of Helsinki, Helsinki, Finland
- Toni Matic
- 7Department of Pediatrics, University Hospital Center Zagreb, Zagreb, Croatia
- Jochen Buechner
- 8Department of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo, Norway
- Anita Lawitschka
- 0Stem Cell Transplantation-Unit, Department of Pediatrics, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria
- Christina Peters
- 0Stem Cell Transplantation-Unit, Department of Pediatrics, St. Anna Children's Hospital, Medical University of Vienna, Vienna, Austria
- Akif Yesilipek
- 9Department of Pediatric Hematology and Pediatric Stem Cell Transplantation Unit, Antalya and Göztepe Medicalpark Hospitals, Antalya, Turkey
- Koray Yalçin
- 0Department of Pediatric Bone Marrow Transplantation Unit, Medicalpark Göztepe Hospital, Istanbul, Turkey
- Giovanna Lucchini
- 1Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, National Health Service Foundation Trust, London, United Kingdom
- Shahrzad Bakhtiar
- 0Division for Stem Cell Transplantation, Immunology and Intensive Care Medicine, Hospital for Children and Adolescents, University Hospital, Goethe University, Frankfurt am Main, Germany
- Dominik Turkiewicz
- 2Division of Molecular Hematology, Lund University, Lund, Sweden
- Riitta Niinimäki
- 3Department of Pediatrics, Oulu University Hospital, Oulu, Finland
- Jacek Wachowiak
- 4Department of Pediatric Oncology, Hematology and Hematopoietic Stem Cell Transplantation, Poznan University of Medical Sciences, Poznan, Poland
- Simone Cesaro
- 5Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
- Arnaud Dalissier
- 6European Society for Blood and Marrow Transplantation Paris Office, Hôpital Saint Antoine, Paris, France
- Selim Corbacioglu
- 7Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University Hospital of Regensburg, Regensburg, Germany
- Andre Manfred Willasch
- 0Division for Stem Cell Transplantation, Immunology and Intensive Care Medicine, Hospital for Children and Adolescents, University Hospital, Goethe University, Frankfurt am Main, Germany
- Peter Bader
- 0Division for Stem Cell Transplantation, Immunology and Intensive Care Medicine, Hospital for Children and Adolescents, University Hospital, Goethe University, Frankfurt am Main, Germany
- DOI
- https://doi.org/10.3389/fped.2021.705179
- Journal volume & issue
-
Vol. 9
Abstract
Specific protocols define eligibility, conditioning, donor selection, graft composition and prophylaxis of graft vs. host disease for children and young adults undergoing hematopoietic stem cell transplant (HSCT). However, international protocols rarely, if ever, detail supportive care, including pharmaceutical infection prophylaxis, physical protection with face masks and cohort isolation or food restrictions. Supportive care suffers from a lack of scientific evidence and implementation of practices in the transplant centers brings extensive restrictions to the child's and family's daily life after HSCT. Therefore, the Board of the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) held a series of dedicated workshops since 2017 with the aim of initiating the production of a set of minimal recommendations. The present paper describes the consensus reached within the field of infection prophylaxis.
Keywords
- infection precaution
- allogeneic hematological stem cell transplantation
- children
- antibiotic prophylactic therapy
- vaccination
