ROLE OF PPAR-* IN DETERMINATION OF MUSCLE FIBER TYPE IN RESPONSE TO EXERCISE

Abstract

Endurance exercise can induce muscle fiber type change from type II glycolytic to oxidative type I muscle fibers. The exact molecular mechanism is still not clear, but the nuclear receptor PPAR-* (peroxisome proliferator-activated receptor delta) and co-activator, perxisome-proliferator-activated receptor-gama co-activator-1" (PGC-1") are the key factors responsible for increased mitochondrial biogenesis and increased oxidative capacity of muscle fibers, determining in this way the muscle phenotype. The paper explores the possible mechanisms of regulation and the role of PPAR-* in the skeletal muscle and muscle fiber type determination in order to find solutions for complex physiological properties, such as fatigue and endurance.

Keywords

• nuclear receptor
• muscle fiber type
• exercise