One-step Selective Synthesis of 13-epi-manoyl Oxide

Abstract

The selective one-step synthesis of 13-epi-manoyl oxide is reported based on a low-temperature superacidic cyclization of sclareol. The reaction conditions have been finely tuned in order to achieve a 9:1 ratio between epimeric oxides in favor of the desired 13-epi-oxide.

Keywords

• sclareol
• cyclization
• superacid
• ether
• labdane