The Central Roles of Noncoding RNA in Estrogen-Dependent Female Reproductive System Tumors

Jiajie Tu; Huan Yang; Lei Jiang; Yu Chen; Yu Chen; Zhe Li; Lei Li; Yuanyuan Zhang; Xiaochun Chen; He Chen; Zhiying Yu

doi:10.1155/2021/5572063

International Journal of Endocrinology (Jan 2021)

The Central Roles of Noncoding RNA in Estrogen-Dependent Female Reproductive System Tumors

Jiajie Tu,
Huan Yang,
Lei Jiang,
Yu Chen,
Yu Chen,
Zhe Li,
Lei Li,
Yuanyuan Zhang,
Xiaochun Chen,
He Chen,
Zhiying Yu

Affiliations

Jiajie Tu: Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Hefei, China
Huan Yang: Department of Gynecology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China
Lei Jiang: Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, Hefei, China
Yu Chen: Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
Yu Chen: Department of Gynecology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China
Zhe Li: The First Clinical Medical College of Southern Medical University, Guangzhou, China
Lei Li: Department of Gynecology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China
Yuanyuan Zhang: Department of Gynecology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China
Xiaochun Chen: Department of Gynecology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China
He Chen: Department of Gynecology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China
Zhiying Yu: Department of Gynecology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China

DOI: https://doi.org/10.1155/2021/5572063
Journal volume & issue: Vol. 2021

Abstract

Read online

The pathogenesis of ovarian and endometrial cancers is closely associated with estrogen-related pathways. These estrogen-dependent tumors seriously threaten the health and quality of life in women. Noncoding RNAs (ncRNAs) are defined as RNAs that do not encode proteins, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), both of which have been reported in estrogen-dependent female reproductive system tumors. This review systematically summarizes the role of ncRNAs in estrogen-dependent tumors and common patterns of regulatory mechanisms to explore their future research directions in tumor diagnosis, treatment, and prognosis. This may provide new ideas for the potential application of ncRNAs in estrogen-dependent female reproductive system tumors.

Published in International Journal of Endocrinology

ISSN: 1687-8337 (Print); 1687-8345 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://onlinelibrary.wiley.com/journal/1573

About the journal