The role of oxidative stress in the development of Alzheimer's disease

Abstract

Oxidative stress is one of the main mechanisms for the development of Alzheimer's disease (AD); it is closely related to other key mechanisms of neurodegeneration such as mitochondrial dysfunction, inflammation, dysregulation of metal homeostasis, and protein misfolding. We have considered the role of beta-amyloid plaques and neurofibrillary tau-glomeruli in the development of AD. We analyzed the role of the products of oxidation of proteins, lipids and nucleic acids in the pathogenesis of the disease, which can be considered as markers of an early stage of AD. The main mechanisms of mitochondrial dysfunction, the damaging effect of accumulating metals under oxidative stress, as well as the role of brain hypoperfusion in its occurrence are considered.

Keywords

• alzheimer's disease
• beta-amyloid
• tau-glomeruli
• mitochondrial dysfunction
• cerebral hypoperfusion