CD200–CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma

Pedram Shafiei-Jahani; Doumet Georges Helou; Benjamin P. Hurrell; Emily Howard; Christine Quach; Jacob D. Painter; Lauriane Galle-Treger; Meng Li; Yong-Hwee Eddie Loh; Omid Akbari

doi:10.1038/s41467-021-22832-7

Nature Communications (May 2021)

CD200–CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma

Pedram Shafiei-Jahani,
Doumet Georges Helou,
Benjamin P. Hurrell,
Emily Howard,
Christine Quach,
Jacob D. Painter,
Lauriane Galle-Treger,
Meng Li,
Yong-Hwee Eddie Loh,
Omid Akbari

Affiliations

Pedram Shafiei-Jahani: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Doumet Georges Helou: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Benjamin P. Hurrell: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Emily Howard: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Christine Quach: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Jacob D. Painter: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Lauriane Galle-Treger: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Meng Li: Norris Medical Bioinformatics, Keck School of Medicine, University of Southern California
Yong-Hwee Eddie Loh: Norris Medical Bioinformatics, Keck School of Medicine, University of Southern California
Omid Akbari: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California

DOI: https://doi.org/10.1038/s41467-021-22832-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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The role of the CD200–CD200R axis in regulating pulmonary inflammation is not completely understood. Here the authors show CD200R is expressed on type 2 innate lymphoid cells (ILC2s), and its engagement by CD200 ameliorates airway hyperreactivity and allergic asthma via inhibition of NF-κB signaling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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