Nature Communications (Jan 2021)
Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins
Abstract
The innate immune system and inflammation modulate bone homeostasis through complex regulation of bone remodelling cells including osteoblasts and osteoclasts. Here, the authors show that the type I interferon pathway and guanylate binding proteins functionally limit bone loss by inhibiting osteoclast functions.