Nature Communications (Jan 2021)

Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins

  • David E. Place,
  • R. K. Subbarao Malireddi,
  • Jieun Kim,
  • Peter Vogel,
  • Masahiro Yamamoto,
  • Thirumala-Devi Kanneganti

DOI
https://doi.org/10.1038/s41467-020-20807-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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The innate immune system and inflammation modulate bone homeostasis through complex regulation of bone remodelling cells including osteoblasts and osteoclasts. Here, the authors show that the type I interferon pathway and guanylate binding proteins functionally limit bone loss by inhibiting osteoclast functions.