Decreased NK cell activity after partial vulvectomy in pregnant patient with vulvar intraepithelial neoplasia 3 (VIN3)

Abstract

Introduction and objective The study presents the problem of immune disturbances in pregnant women with vulvar carcinoma in situ (VIN3). Material and Methods NK cell and T reg activity in the study patient were analysed using flow cytometry. Results Decreased NK cell activity and but increased T reg activity were observed after vulvectomy, with subsequent successful pregnancy outcome. Conclusions Although vulvar cancer may influence immune cell activity, this issue merits further study.

Keywords

• vulvar cancer
• NK cell
• Pregnancy
• T reg