KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants

Marija Herholz; Estela Cepeda; Linda Baumann; Alexandra Kukat; Johannes Hermeling; Sarah Maciej; Karolina Szczepanowska; Victor Pavlenko; Peter Frommolt; Aleksandra Trifunovic

doi:10.1038/s41467-019-11275-w

Nature Communications (Jul 2019)

KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants

Marija Herholz,
Estela Cepeda,
Linda Baumann,
Alexandra Kukat,
Johannes Hermeling,
Sarah Maciej,
Karolina Szczepanowska,
Victor Pavlenko,
Peter Frommolt,
Aleksandra Trifunovic

Affiliations

Marija Herholz: Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Institute for Mitochondrial Diseases and Ageing, Medical Faculty, University of Cologne
Estela Cepeda: Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Institute for Mitochondrial Diseases and Ageing, Medical Faculty, University of Cologne
Linda Baumann: Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Institute for Mitochondrial Diseases and Ageing, Medical Faculty, University of Cologne
Alexandra Kukat: Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Institute for Mitochondrial Diseases and Ageing, Medical Faculty, University of Cologne
Johannes Hermeling: Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Institute for Mitochondrial Diseases and Ageing, Medical Faculty, University of Cologne
Sarah Maciej: Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Institute for Mitochondrial Diseases and Ageing, Medical Faculty, University of Cologne
Karolina Szczepanowska: Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Institute for Mitochondrial Diseases and Ageing, Medical Faculty, University of Cologne
Victor Pavlenko: Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Institute for Mitochondrial Diseases and Ageing, Medical Faculty, University of Cologne
Peter Frommolt: Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Institute for Mitochondrial Diseases and Ageing, Medical Faculty, University of Cologne
Aleksandra Trifunovic: Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD) and Institute for Mitochondrial Diseases and Ageing, Medical Faculty, University of Cologne

DOI: https://doi.org/10.1038/s41467-019-11275-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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Cytochrome P450 oxidases (CYPs) are enzymes that participate in the xenobiotic detoxification and their expression is enhanced in long-lived model organisms. Here the authors show that KLF-1 promotes cyp expression and ensures lifespan extension in C. elegans mitomutants by activating mitohormesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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