Xanthones from the Roots of Moutabea guianensis Aubl.
Haroldo da S. Ripardo Filho,
Luidi C. Pacheco,
Edinaldo da S. Andrade,
Marivaldo José C. Correa,
Railda Neyva M. Araújo,
Giselle Maria S. P. Guilhon,
Joyce Kelly R. da Silva,
Lourivaldo S. Santos
Affiliations
Haroldo da S. Ripardo Filho
Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará-UFPA, Rua Augusto Corrêa, S/N, 66075-900 Belém-PA, Brazil
Luidi C. Pacheco
Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará-UFPA, Rua Augusto Corrêa, S/N, 66075-900 Belém-PA, Brazil
Edinaldo da S. Andrade
Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará-UFPA, Rua Augusto Corrêa, S/N, 66075-900 Belém-PA, Brazil
Marivaldo José C. Correa
Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará-UFPA, Rua Augusto Corrêa, S/N, 66075-900 Belém-PA, Brazil
Railda Neyva M. Araújo
Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará-UFPA, Rua Augusto Corrêa, S/N, 66075-900 Belém-PA, Brazil
Giselle Maria S. P. Guilhon
Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará-UFPA, Rua Augusto Corrêa, S/N, 66075-900 Belém-PA, Brazil
Joyce Kelly R. da Silva
Programa de Pós-Graduação em Biotecnologia, Instituto de Ciências Biológicas, Universidade Federal do Pará-UFPA, Rua Augusto Corrêa, S/N, 66075-900 Belém-PA, Brazil
Lourivaldo S. Santos
Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará-UFPA, Rua Augusto Corrêa, S/N, 66075-900 Belém-PA, Brazil
The phytochemical investigation of Moutabea guianensis roots led to the isolation of five polyoxygenated xanthones, including two new ones named moutabeone B (1,8-dihydroxy-4,5,6,7-tetramethoxyxanthone) and moutabeone C (1-hydroxy-4,5,6,7,8-pentamethoxyxanthone), along with the three known xanthones, 1,8-dihydroxy-4,6-dimethoxyxanthone, 1,8-dihydroxy-4,5,6-trimethoxyxanthone and augustin A (1,8-dihydroxy-4,6,7-trimethoxyxanthone). Structural characterization of all compounds was established on the basis of spectroscopic methods, mainly 1D and 2D nuclear magnetic resonance (NMR) and comparison with literature data. The antioxidant activity of compounds was tested through a thin layer chromatography (TLC) bioautography assay using 1,1-diphenyl-2-picryl-hydrazyl radical (DPPH·) as detection reagent. All tested compounds were more active (DL < 0.13–0.03 µg) than Trolox (DL < 0.15 µg), used as reference standard.
