Combatting antibiotic resistance by exploring the promise of Quorum Quenching in targeting bacterial virulence
Krishna Patel,
Riddhi Panchal,
Bhautik Sakariya,
Miral Gevariya,
Riddhi Raiyani,
Richa Soni,
Dweipayan Goswami
Affiliations
Krishna Patel
Department of Microbiology & Biotechnology, University School of Sciences, Gujarat University, Ahmedabad, Gujarat 380009, India
Riddhi Panchal
Department of Microbiology & Biotechnology, University School of Sciences, Gujarat University, Ahmedabad, Gujarat 380009, India
Bhautik Sakariya
Department of Microbiology & Biotechnology, University School of Sciences, Gujarat University, Ahmedabad, Gujarat 380009, India
Miral Gevariya
Department of Microbiology & Biotechnology, University School of Sciences, Gujarat University, Ahmedabad, Gujarat 380009, India
Riddhi Raiyani
Department of Microbiology & Biotechnology, University School of Sciences, Gujarat University, Ahmedabad, Gujarat 380009, India
Richa Soni
Department of Life Sciences, Food Science & Nutrition, University School of Sciences, Gujarat University, Ahmedabad, Gujarat 380009, India; Corresponding author.
Dweipayan Goswami
Department of Microbiology & Biotechnology, University School of Sciences, Gujarat University, Ahmedabad, Gujarat 380009, India; Department of Microbiology and Immunology at the Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria 3000, Australia; Corresponding author at: Department of Microbiology & Biotechnology, University School of Sciences, Gujarat University, Ahmedabad, Gujarat 380009, India.
The escalating global crisis of antibiotic resistance demands innovative approaches to overcome the limitations of conventional antimicrobial therapies. Quorum Sensing (QS) is a mechanism of microbial communication through extracellular chemical signals and is responsible for the regulation of crucial processes such as sporulation, biofilm production, and virulence. As such, QS inhibition has emerged as a promising alternative strategy to inhibit important bacterial functions, without exerting direct selective pressure on bacterial growth. Here, we highlight the use of Quorum Quenching (QQ) mechanisms, including quorum sensing inhibitors (QSIs) derived from bioactive chemicals and essential oils of plants, as a means to control infections and discuss the practical challenges associated with implementing QQ in real-world settings, including delivery methods, dosages, and compatibility with existing treatments. Despite these challenges, ongoing research in QQ continues to explore innovative approaches to overcome these obstacles and harness the potential of disrupting bacterial communication for therapeutic and biotechnological applications.
