Physics and Imaging in Radiation Oncology (Oct 2019)

Comparison of biophysical models with experimental data for three cell lines in response to irradiation with monoenergetic ions

  • Caterina Monini,
  • Gersende Alphonse,
  • Claire Rodriguez-Lafrasse,
  • Étienne Testa,
  • Michaël Beuve

Journal volume & issue
Vol. 12
pp. 17 – 21

Abstract

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The relative biological effectiveness (RBE) in particle therapy is currently estimated using biophysical models. We compared experimental measurements to the α curves as function of linear energy transfer computed by the Local Effect Model (LEM I-IV), the Microdosimetric Kinetic Model (MKM) and the NanOx model for HSG, V79 and CHO-K1 cells in response to monoenergetic irradiations. Although the LEM IV and the MKM predictions accurately reproduced the trend observed in the data, NanOx yielded a better agreement than the other models for more irradiation configurations. Its χ2 estimator was indeed the lowest for three over seven considered cases. Keywords: Hadrontherapy, Biophysical modeling, Monoenergetic ions, Benchmark