Molecular regulation after mucosal injury and regeneration in ulcerative colitis

Lie Zheng; Sheng-Lei Duan; Xin-Li Wen; Yan-Cheng Dai

doi:10.3389/fmolb.2022.996057

Frontiers in Molecular Biosciences (Oct 2022)

Molecular regulation after mucosal injury and regeneration in ulcerative colitis

Lie Zheng,
Sheng-Lei Duan,
Xin-Li Wen,
Yan-Cheng Dai

Affiliations

Lie Zheng: Department of Gastroenterology, Shaanxi Hospital of Traditional Chinese Medicine, Xi’an, Shaanxi Province, China
Sheng-Lei Duan: Department of Gastroenterology, Shaanxi Hospital of Traditional Chinese Medicine, Xi’an, Shaanxi Province, China
Xin-Li Wen: Department of Gastroenterology, Shaanxi Hospital of Traditional Chinese Medicine, Xi’an, Shaanxi Province, China
Yan-Cheng Dai: Department of Gastroenterology, Shanghai Traditional Chinese Medicine Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

DOI: https://doi.org/10.3389/fmolb.2022.996057
Journal volume & issue: Vol. 9

Abstract

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Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease with a complex etiology. Intestinal mucosal injury is an important pathological change in individuals with UC. Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5+) intestinal stem cells (ISCs) exhibit self-renewal and high differentiation potential and play important roles in the repair of intestinal mucosal injury. Moreover, LGR5+ ISCs are intricately regulated by both the Wnt/β-catenin and Notch signaling pathways, which jointly maintain the function of LGR5+ ISCs. Combination therapy targeting multiple signaling pathways and transplantation of LGR5+ ISCs may lead to the development of new clinical therapies for UC.

Published in Frontiers in Molecular Biosciences

ISSN: 2296-889X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/molecular-biosciences

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Abstract

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