Role of lipotoxicity in achieving glycemic control in patients with diabetes type 2 and obesity

Abstract

Obesity increases the risk of diabetes mellitus type 2 due to the development of insulin resistance. Therapy for diabetes mellitus type 2 is limited by a relatively small amount of knowledge on the mechanisms of insulin resistance, despite the availability of several scientifically valid hypotheses about its origin. These theories focus on inflammation, mitochondrial dysfunction, hyperinsulinemia and lipotoxicity as playing the key role in the process. Absence of a general pathogenic mechanism of insulin resistance which combines all of the theories attracts attention to the issue. At the same time, none of the mentioned concepts or views resulted in an improvement or higher efficiency of treatment for diabetes mellitus type 2.

Keywords

• липотоксичность
• гиперинсулинемия
• инсулинорезистентность
• lipotoxicity
• hyperinsulinemia
• insulin resistance