Nature Communications (Nov 2022)
Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation
- Bartosz Mucha,
- Shuo Qie,
- Sagar Bajpai,
- Vincenzo Tarallo,
- J. Nathaniel Diehl,
- Frank Tedeschi,
- Gao Zhou,
- Zhaofeng Gao,
- Samuel Flashner,
- Andres J. Klein-Szanto,
- Hanina Hibshoosh,
- Shimonosono Masataka,
- Olga S. Chajewski,
- Ireneusz Majsterek,
- Dariusz Pytel,
- Maria Hatzoglou,
- Channing J. Der,
- Hiroshi Nakagawa,
- Adam J. Bass,
- Kwok-Kin Wong,
- Serge Y. Fuchs,
- Anil K. Rustgi,
- Eckhard Jankowsky,
- J. Alan Diehl
Affiliations
- Bartosz Mucha
- Department of Biochemistry, Case Comprehensive Cancer Center, Case Western Reserve University
- Shuo Qie
- Department of Biochemistry, Case Comprehensive Cancer Center, Case Western Reserve University
- Sagar Bajpai
- Department of Biochemistry, Case Comprehensive Cancer Center, Case Western Reserve University
- Vincenzo Tarallo
- Department of Biochemistry, Case Comprehensive Cancer Center, Case Western Reserve University
- J. Nathaniel Diehl
- Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill
- Frank Tedeschi
- Department of Biochemistry, Case Comprehensive Cancer Center, Case Western Reserve University
- Gao Zhou
- Center for RNA Science and Therapeutics, Case Comprehensive Cancer Center, Case Western Reserve University
- Zhaofeng Gao
- Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University
- Samuel Flashner
- Division of Hematology-Oncology, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center
- Andres J. Klein-Szanto
- Histopathology Facility, Fox Chase Cancer Center
- Hanina Hibshoosh
- Division of Hematology-Oncology, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center
- Shimonosono Masataka
- Division of Hematology-Oncology, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center
- Olga S. Chajewski
- Department of Pathology and Laboratory Medicine, Medical University of South Carolina
- Ireneusz Majsterek
- Department of Clinical Chemistry and Biochemistry, Medical University of Lodz
- Dariusz Pytel
- Department of Pathology and Laboratory Medicine, Medical University of South Carolina
- Maria Hatzoglou
- Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University
- Channing J. Der
- Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill
- Hiroshi Nakagawa
- Division of Digestive and Liver Diseases, Department of Medicine, Herbert Irving Comprehensive Cancer Research Center, Columbia University Irving Medical Center
- Adam J. Bass
- Division of Hematology-Oncology, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center
- Kwok-Kin Wong
- Division of Hematology and Medical Oncology, Perlmutter Cancer Center, New York University
- Serge Y. Fuchs
- Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania
- Anil K. Rustgi
- Division of Digestive and Liver Diseases, Department of Medicine, Herbert Irving Comprehensive Cancer Research Center, Columbia University Irving Medical Center
- Eckhard Jankowsky
- Department of Biochemistry, Case Comprehensive Cancer Center, Case Western Reserve University
- J. Alan Diehl
- Department of Biochemistry, Case Comprehensive Cancer Center, Case Western Reserve University
- DOI
- https://doi.org/10.1038/s41467-022-34402-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Cytoplasmic accumulation of RNA binding protein, hnRNPK in cancer cells is associated with poor prognosis. Here the authors show that SCFFbxo4 E3 ubiquitin ligase-mediated polyubiquitylation of hnRNPK restricts c-Myc translation and limits cancer progression.
