Nature Communications (Nov 2022)
Glycolytic flux control by drugging phosphoglycolate phosphatase
- Elisabeth Jeanclos,
- Jan Schlötzer,
- Kerstin Hadamek,
- Natalia Yuan-Chen,
- Mohammad Alwahsh,
- Robert Hollmann,
- Stefanie Fratz,
- Dilan Yesilyurt-Gerhards,
- Tina Frankenbach,
- Daria Engelmann,
- Angelika Keller,
- Alexandra Kaestner,
- Werner Schmitz,
- Martin Neuenschwander,
- Roland Hergenröder,
- Christoph Sotriffer,
- Jens Peter von Kries,
- Hermann Schindelin,
- Antje Gohla
Affiliations
- Elisabeth Jeanclos
- Institute of Pharmacology and Toxicology, University of Würzburg
- Jan Schlötzer
- Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg
- Kerstin Hadamek
- Institute of Pharmacology and Toxicology, University of Würzburg
- Natalia Yuan-Chen
- Institute of Pharmacy and Food Chemistry, University of Würzburg
- Mohammad Alwahsh
- Leibniz-Institut für analytische Wissenschaften-ISAS
- Robert Hollmann
- Leibniz-Institut für analytische Wissenschaften-ISAS
- Stefanie Fratz
- Institute of Pharmacology and Toxicology, University of Würzburg
- Dilan Yesilyurt-Gerhards
- Institute of Pharmacology and Toxicology, University of Würzburg
- Tina Frankenbach
- Institute of Pharmacology and Toxicology, University of Würzburg
- Daria Engelmann
- Institute of Pharmacology and Toxicology, University of Würzburg
- Angelika Keller
- Institute of Pharmacology and Toxicology, University of Würzburg
- Alexandra Kaestner
- Institute of Pharmacology and Toxicology, University of Würzburg
- Werner Schmitz
- Department of Biochemistry and Molecular Biology, Theodor Boveri Institute, Biocenter, University of Würzburg
- Martin Neuenschwander
- Leibniz-Forschungsinstitut für Molekulare Pharmakologie-FMP
- Roland Hergenröder
- Leibniz-Institut für analytische Wissenschaften-ISAS
- Christoph Sotriffer
- Institute of Pharmacy and Food Chemistry, University of Würzburg
- Jens Peter von Kries
- Leibniz-Forschungsinstitut für Molekulare Pharmakologie-FMP
- Hermann Schindelin
- Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg
- Antje Gohla
- Institute of Pharmacology and Toxicology, University of Würzburg
- DOI
- https://doi.org/10.1038/s41467-022-34228-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Targeting cellular glucose metabolism is a therapeutic strategy in human diseases such as autoimmunity or cancer. Here, the authors demonstrate the druggability of phosphoglycolate phosphatase, and validate an alternative approach to control glycolysis.
