Nature Communications (Jun 2021)

Hakai is required for stabilization of core components of the m6A mRNA methylation machinery

  • Praveen Bawankar,
  • Tina Lence,
  • Chiara Paolantoni,
  • Irmgard U. Haussmann,
  • Migle Kazlauskiene,
  • Dominik Jacob,
  • Jan B. Heidelberger,
  • Florian M. Richter,
  • Mohanakarthik P. Nallasivan,
  • Violeta Morin,
  • Nastasja Kreim,
  • Petra Beli,
  • Mark Helm,
  • Martin Jinek,
  • Matthias Soller,
  • Jean-Yves Roignant

DOI
https://doi.org/10.1038/s41467-021-23892-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

Read online

The E3 ligase Hakai can interact with the m6A methylation machinery but its function is still unclear. Here, the authors show that Hakai is a conserved component of the m6A methyltransferase complex and provide functional and molecular insights into its role in regulating m6A levels in Drosophila.