IL-6, IL-8, TNF-α and C-Reactive Protein Levels in the Diagnosis and Prognosis of Neonatal Sepsis

Abstract

INTRODUCTION: The aim of the study was to determine the importance and reliability of IL-6, IL8, TNF-α and C-reactive protein (CRP) levels in terms of diagnosis and prognosis in neonatal sepsis. METHODS: Thirty newborns who were followed up and treated with the prediagnosis of neonatal sepsis in Neonatal Intensive Care Unit and 20 healthy newborns born to mothers without any disease were included in the study. Gender, gestational age, postnatal age, place and type of birth, birth weight, IL-6, IL-8, TNF-α and CRP levels of the cases were recorded. RESULTS: Of the 30 cases diagnosed clinically as sepsis, 16 (53.3%) were male and 14 (46.7%) were female. Of the 20 cases in the control group, 11 (55%) were male and 9 (45%) were female. Eight (26.6%) of 30 sepsis cases were accepted as early-onset and 22 (73.4%) late-onset neonatal sepsis While the mortality rate in early-onset sepsis was 25%, this rate was 36.3% in late-onset sepsis cases. C-reactive protein, Interleukin-6, and Interleukin-8 were found to be statistically significantly higher in the group of cases than in the control group. Tumor necrosis factor-α levels were statistically similar in both groups. IL-6 (p: 0.001) and IL-8 (p: 0.007) levels were found to be statistically significantly higher in deceased cases. DISCUSSION AND CONCLUSION: C-reactive protein, Interleukin-6, Interleukin-8 levels in the diagnosis of neonatal sepsis found as parameters that can be used, TNF-α was not found to have diagnostic value. IL-6 and IL-8 levels were found to be significant in neonatal sepsis prognosis.

Keywords

• neonatal sepsis
• gestational age
• c- reactive protein