Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer

Matteo D′Antonio; Donate Weghorn; Agnieszka D′Antonio-Chronowska; Florence Coulet; Katrina M. Olson; Christopher DeBoever; Frauke Drees; Angelo Arias; Hakan Alakus; Andrea L. Richardson; Richard B. Schwab; Emma K. Farley; Shamil R. Sunyaev; Kelly A Frazer

doi:10.1038/s41467-017-00100-x

Nature Communications (Sep 2017)

Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer

Matteo D′Antonio,
Donate Weghorn,
Agnieszka D′Antonio-Chronowska,
Florence Coulet,
Katrina M. Olson,
Christopher DeBoever,
Frauke Drees,
Angelo Arias,
Hakan Alakus,
Andrea L. Richardson,
Richard B. Schwab,
Emma K. Farley,
Shamil R. Sunyaev,
Kelly A Frazer

Affiliations

Matteo D′Antonio: Moores Cancer Center, University of California
Donate Weghorn: Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School
Agnieszka D′Antonio-Chronowska: Institute for Genomic Medicine, University of California
Florence Coulet: Department of Pediatrics, University of California
Katrina M. Olson: Department of Medicine, Division of Cardiology, University of California
Christopher DeBoever: Bioinformatics and Systems Biology, University of California
Frauke Drees: Department of Pediatrics, University of California
Angelo Arias: Department of Pediatrics, University of California
Hakan Alakus: Department of Pediatrics, University of California
Andrea L. Richardson: Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School
Richard B. Schwab: Moores Cancer Center, University of California
Emma K. Farley: Department of Medicine, Division of Cardiology, University of California
Shamil R. Sunyaev: Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School
Kelly A Frazer: Moores Cancer Center, University of California

DOI: https://doi.org/10.1038/s41467-017-00100-x
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

Read online

Cancer driver mutations can occur within noncoding genomic sequences. Here, the authors develop a statistical approach to identify candidate noncoding driver mutations in DNase I hypersensitive sites in breast cancer and experimentally demonstrate they are regulatory elements of known cancer genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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