Changes in systemic inflammatory and nasal mucociliary response following smoking cessation

Abstract

Introduction: This study aimed to evaluate the changesboth in the systemic inflammation and in the mucociliary clearance followingsmoking cessation, and their associations with smoking characteristics.Methods: A total of 30 cases admitted to Konya Training andResearch Hospital, University of Health Sciences, Department of SmokingCessation were recruited, and 27 of them completed the study. Tumor necrosisfactor alpha (TNF-α), interleukin (IL) -4, IL-6, IL-8, IL-10 and saccharintransit time (STT) was measuredat the beginning and 2 months after smokingcessation.Results: We found in this study that STT decreased significantlyin 2 months after cessation (p lt;0.001). In our study, we found that serumTNF-α (p=0.035) and IL-8 (p=0.002) levels were decreased significantly at 2months after quitting when compared with the basal levels. In our study, serumIL-6 (p=0.132) and IL-10 (p=0.657) levels did not change significantly in the2nd month of quitting, when compared to basal levels.Conclusion: In this study, two months after smoking cessation,nasal mucosal clearance and systemic inflammatory response especially plasmaTNF- α and IL-8 levels were improved. We think that further studies with largersample size and longer follow-up will provide more detailed data about theimprovements in systemic inflammation.

Keywords

• sistemik inflamasyon
• sitokin
• sakarin geçiş süresi
• sigara bırakma
• systemic inflammation
• cytokines
• saccharin transit time
• smoking cessation