Nature Communications (Dec 2022)
The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3
- Ryosuke Ishimura,
- Afnan H. El-Gowily,
- Daisuke Noshiro,
- Satoko Komatsu-Hirota,
- Yasuko Ono,
- Mayumi Shindo,
- Tomohisa Hatta,
- Manabu Abe,
- Takefumi Uemura,
- Hyeon-Cheol Lee-Okada,
- Tarek M. Mohamed,
- Takehiko Yokomizo,
- Takashi Ueno,
- Kenji Sakimura,
- Tohru Natsume,
- Hiroyuki Sorimachi,
- Toshifumi Inada,
- Satoshi Waguri,
- Nobuo N. Noda,
- Masaaki Komatsu
Affiliations
- Ryosuke Ishimura
- Department of Physiology, Juntendo University Graduate School of Medicine, Bunkyo-ku
- Afnan H. El-Gowily
- Department of Physiology, Juntendo University Graduate School of Medicine, Bunkyo-ku
- Daisuke Noshiro
- Division of Biological Molecular Mechanisms, Institute for Genetic Medicine, Hokkaido University
- Satoko Komatsu-Hirota
- Department of Physiology, Juntendo University Graduate School of Medicine, Bunkyo-ku
- Yasuko Ono
- Calpain Project, Department of Basic Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku
- Mayumi Shindo
- Advanced Technical Support Department, Center for Basic Technology Research, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku
- Tomohisa Hatta
- National Institutes of Advanced Industrial Science and Technology, Biological Information Research Center (JBIRC), Kohtoh-ku
- Manabu Abe
- Department of Animal Model Development, Brain Research Institute, Niigata University, Chuo-ku
- Takefumi Uemura
- Department of Anatomy and Histology, Fukushima Medical University School of Medicine, Hikarigaoka
- Hyeon-Cheol Lee-Okada
- Department of Biochemistry, Juntendo University Graduate School of Medicine, Bunkyo-ku
- Tarek M. Mohamed
- Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University
- Takehiko Yokomizo
- Department of Biochemistry, Juntendo University Graduate School of Medicine, Bunkyo-ku
- Takashi Ueno
- Laboratory of Proteomics and Biomolecular Science, Biomedical Research Core Facilities, Juntendo University Graduate School of Medicine, Bunkyo-ku
- Kenji Sakimura
- Department of Animal Model Development, Brain Research Institute, Niigata University, Chuo-ku
- Tohru Natsume
- National Institutes of Advanced Industrial Science and Technology, Biological Information Research Center (JBIRC), Kohtoh-ku
- Hiroyuki Sorimachi
- Calpain Project, Department of Basic Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku
- Toshifumi Inada
- Division of RNA and gene regulation, Institute of Medical Science, The University of Tokyo
- Satoshi Waguri
- Department of Anatomy and Histology, Fukushima Medical University School of Medicine, Hikarigaoka
- Nobuo N. Noda
- Division of Biological Molecular Mechanisms, Institute for Genetic Medicine, Hokkaido University
- Masaaki Komatsu
- Department of Physiology, Juntendo University Graduate School of Medicine, Bunkyo-ku
- DOI
- https://doi.org/10.1038/s41467-022-35501-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
The UFM1 system, a ubiquitin-like conjugation system is crucial for endoplasmic reticulum (ER) homeostasis. Here, authors found that CYB5R3 is covalently conjugated with UFM1, which becomes a signal for ER-phagy, a selective autophagy of ER.
