CELIAC DISEASE IN CHILDREN: SOLVED AND UNSOLVED QUESTIONS OF AETIOPATHOGENESIS

Abstract

In the recent decade, thanks to rapid development of new immunologic, morphologic and biologic methods we have achieved dramatic progress in understanding of celiac disease aetiopathogenesis. The whole image of the disease has been changed and enlarged — now it’s defined as an immunemediated multisystemic disease, that is caused by gluten and corresponding prolamines among genetically vulnerable individuals, that is characterized by a variety of gluten-dependant clinical features, specific antibodies, HLA DQ2 and DQ8 haplotypes and enteropathy. According to this novel approach, we regard possibilities of celiac disease diagnostic algorithm improvement, especially among patients from risk groups.Key words: celiac disease, autoimmune disease, enteropathy, gluten, gliadine peptides, tissue transglutaminase, haplotypes HLA DQ2, DQ8.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2011; 10 (4): 30–35)