Nature Communications (Apr 2020)

Consistent RNA sequencing contamination in GTEx and other data sets

  • Tim O. Nieuwenhuis,
  • Stephanie Y. Yang,
  • Rohan X. Verma,
  • Vamsee Pillalamarri,
  • Dan E. Arking,
  • Avi Z. Rosenberg,
  • Matthew N. McCall,
  • Marc K. Halushka

DOI
https://doi.org/10.1038/s41467-020-15821-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

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Sample contamination has been reported in high throughput RNA sequencing. Here the authors analyze the RNA sequencing data from the Genotype-Tissue Expression project and describe how highly expressed, tissue specific genes contaminate across samples, which is corroborated in other data sets.