IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection

Bruce A. Rosa; Mushtaq Ahmed; Dhiraj K. Singh; José Alberto Choreño-Parra; Journey Cole; Luis Armando Jiménez-Álvarez; Tatiana Sofía Rodríguez-Reyna; Bindu Singh; Olga Gonzalez; Ricardo Carrion; Larry S. Schlesinger; John Martin; Joaquín Zúñiga; Makedonka Mitreva; Deepak Kaushal; Shabaana A. Khader

doi:10.1038/s42003-021-01829-4

Communications Biology (Mar 2021)

IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection

Bruce A. Rosa,
Mushtaq Ahmed,
Dhiraj K. Singh,
José Alberto Choreño-Parra,
Journey Cole,
Luis Armando Jiménez-Álvarez,
Tatiana Sofía Rodríguez-Reyna,
Bindu Singh,
Olga Gonzalez,
Ricardo Carrion,
Larry S. Schlesinger,
John Martin,
Joaquín Zúñiga,
Makedonka Mitreva,
Deepak Kaushal,
Shabaana A. Khader

Affiliations

Bruce A. Rosa: Department of Medicine, Washington University in St. Louis
Mushtaq Ahmed: Department of Molecular Microbiology, Washington University in St. Louis
Dhiraj K. Singh: Southwest National Primate Research Center, Texas Biomedical Research Institute
José Alberto Choreño-Parra: Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas
Journey Cole: Southwest National Primate Research Center, Texas Biomedical Research Institute
Luis Armando Jiménez-Álvarez: Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas
Tatiana Sofía Rodríguez-Reyna: Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Bindu Singh: Southwest National Primate Research Center, Texas Biomedical Research Institute
Olga Gonzalez: Southwest National Primate Research Center, Texas Biomedical Research Institute
Ricardo Carrion: Southwest National Primate Research Center, Texas Biomedical Research Institute
Larry S. Schlesinger: Southwest National Primate Research Center, Texas Biomedical Research Institute
John Martin: Department of Medicine, Washington University in St. Louis
Joaquín Zúñiga: Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas
Makedonka Mitreva: Department of Medicine, Washington University in St. Louis
Deepak Kaushal: Southwest National Primate Research Center, Texas Biomedical Research Institute
Shabaana A. Khader: Department of Molecular Microbiology, Washington University in St. Louis

DOI: https://doi.org/10.1038/s42003-021-01829-4
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 14

Abstract

Read online

Rosa et al. find that genes associated with Interferon (IFN) signaling, neutrophil degranulation and innate immune pathways are induced in the lungs of macaques in response to SARS-CoV-2 infection, whereas genes associated with collagen formation and regulation are reduced. Authors also note an overlap of genes associated with SARS-CoV-2 infection and tuberculosis, altogether providing new insights into the immunopathogenesis of COVID-19 disease.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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