Nature Communications (Jul 2021)

Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis

  • Riccardo Biavasco,
  • Emanuele Lettera,
  • Kety Giannetti,
  • Diego Gilioli,
  • Stefano Beretta,
  • Anastasia Conti,
  • Serena Scala,
  • Daniela Cesana,
  • Pierangela Gallina,
  • Margherita Norelli,
  • Luca Basso-Ricci,
  • Attilio Bondanza,
  • Giulio Cavalli,
  • Maurilio Ponzoni,
  • Lorenzo Dagna,
  • Claudio Doglioni,
  • Alessandro Aiuti,
  • Ivan Merelli,
  • Raffaella Di Micco,
  • Eugenio Montini

DOI
https://doi.org/10.1038/s41467-021-24876-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

Read online

BRAF-MAPK activating mutations are reported in histiocytoses—hematological neoplasms with widespread pro-inflammatory myeloid cells. Here, the authors show that an activating mutant BRAF in haematopoietic stem and progenitor cells causes an oncogene-induced senescence response leading to myeloid restricted haematopoiesis, inflammation and histiocytosis.