Single-cell imaging of α and β cell metabolic response to glucose in living human Langerhans islets

Fabio Azzarello; Luca Pesce; Valentina De Lorenzi; Gianmarco Ferri; Marta Tesi; Silvia Del Guerra; Piero Marchetti; Francesco Cardarelli

doi:10.1038/s42003-022-04215-w

Communications Biology (Nov 2022)

Single-cell imaging of α and β cell metabolic response to glucose in living human Langerhans islets

Fabio Azzarello,
Luca Pesce,
Valentina De Lorenzi,
Gianmarco Ferri,
Marta Tesi,
Silvia Del Guerra,
Piero Marchetti,
Francesco Cardarelli

Affiliations

Fabio Azzarello: NEST Laboratory - Scuola Normale Superiore
Luca Pesce: NEST Laboratory - Scuola Normale Superiore
Valentina De Lorenzi: NEST Laboratory - Scuola Normale Superiore
Gianmarco Ferri: NEST Laboratory - Scuola Normale Superiore
Marta Tesi: Department of Clinical and Experimental Medicine, Islet Cell Laboratory, University of Pisa
Silvia Del Guerra: Department of Clinical and Experimental Medicine, Islet Cell Laboratory, University of Pisa
Piero Marchetti: Department of Clinical and Experimental Medicine, Islet Cell Laboratory, University of Pisa
Francesco Cardarelli: NEST Laboratory - Scuola Normale Superiore

DOI: https://doi.org/10.1038/s42003-022-04215-w
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 10

Abstract

Read online

A combination of live imaging and immunofluorescence on donor islet cells uncover an anti-correlation of enzyme-bound NAD(P)H and insulin secretion power.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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