Immunal and biochemical indexes in early diagnostics of chronic brain ischemia

Abstract

The paper presents results of clinical and laboratory investigation of 106 patients with chronic brain ischemia (CBI) I—II stages, included detection levels of circulating desquamated endothelial cells, endothelin-1, autoantibodies to encephalitogenic protein, neuron-specific enolase and protein S100. Reliable changes of immune status as well as signs of endothelium dysfunction progressed with stage of CBI. Direct correlation between intensity of endothelium dysfunction and activity of neurodegererative process in brain was revealed.

Keywords

• хроническая ишемия головного мозга
• дисфункция эндотелия
• нейродегенеративный процесс
• циркулирующие десквамированные эндотелиоциты
• эндотелин-1
• нейроспецифические белки