Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants

James W. Saville; Dhiraj Mannar; Xing Zhu; Shanti S. Srivastava; Alison M. Berezuk; Jean-Philippe Demers; Steven Zhou; Katharine S. Tuttle; Inna Sekirov; Andrew Kim; Wei Li; Dimiter S. Dimitrov; Sriram Subramaniam

doi:10.1038/s41467-022-28324-6

Nature Communications (Feb 2022)

Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants

James W. Saville,
Dhiraj Mannar,
Xing Zhu,
Shanti S. Srivastava,
Alison M. Berezuk,
Jean-Philippe Demers,
Steven Zhou,
Katharine S. Tuttle,
Inna Sekirov,
Andrew Kim,
Wei Li,
Dimiter S. Dimitrov,
Sriram Subramaniam

Affiliations

James W. Saville: Department of Biochemistry and Molecular Biology, University of British Columbia
Dhiraj Mannar: Department of Biochemistry and Molecular Biology, University of British Columbia
Xing Zhu: Department of Biochemistry and Molecular Biology, University of British Columbia
Shanti S. Srivastava: Department of Biochemistry and Molecular Biology, University of British Columbia
Alison M. Berezuk: Department of Biochemistry and Molecular Biology, University of British Columbia
Jean-Philippe Demers: Department of Biochemistry and Molecular Biology, University of British Columbia
Steven Zhou: Department of Biochemistry and Molecular Biology, University of British Columbia
Katharine S. Tuttle: Department of Biochemistry and Molecular Biology, University of British Columbia
Inna Sekirov: BC Centre for Disease Control
Andrew Kim: Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine
Wei Li: Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine
Dimiter S. Dimitrov: Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine
Sriram Subramaniam: Department of Biochemistry and Molecular Biology, University of British Columbia

DOI: https://doi.org/10.1038/s41467-022-28324-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

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Saville, Mannar et al. provide a structural basis for enhanced antibody evasion and ACE2 binding by the Delta SARS-CoV-2 spike protein. They further identify a head-to-head dimer-of-trimers cryoEM reconstruction unique to the Kappa variant spike.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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