Large-scale DNA demethylation occurs in proliferating ovarian granulosa cells during mouse follicular development

Tomoko Kawai; JoAnne S. Richards; Masayuki Shimada

doi:10.1038/s42003-021-02849-w

Communications Biology (Nov 2021)

Large-scale DNA demethylation occurs in proliferating ovarian granulosa cells during mouse follicular development

Tomoko Kawai,
JoAnne S. Richards,
Masayuki Shimada

Affiliations

Tomoko Kawai: Laboratory of Reproductive Biology, Graduate School of Integrated Sciences for Life, Hiroshima University
JoAnne S. Richards: Department of Molecular and Cellular Biology, Baylor College of Medicine
Masayuki Shimada: Laboratory of Reproductive Biology, Graduate School of Integrated Sciences for Life, Hiroshima University

DOI: https://doi.org/10.1038/s42003-021-02849-w
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 15

Abstract

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Tomoko Kawai et al. investigate DNA methylation patterns during granulosa cell differentiation and proliferation. Their results suggest that sequential epigenetic events are essential for progressive changes in granulosa cell differentiation.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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