Nature Communications (Jul 2022)

Expanding chemical space by para-C−H arylation of arenes

  • Sudip Maiti,
  • Yingzi Li,
  • Sheuli Sasmal,
  • Srimanta Guin,
  • Trisha Bhattacharya,
  • Goutam Kumar Lahiri,
  • Robert S. Paton,
  • Debabrata Maiti

DOI
https://doi.org/10.1038/s41467-022-31506-x
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 10

Abstract

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Biaryls are privileged structural motif used in the discovery and design of therapeutics with high affinity and specificity for a broad range of protein targets. Herein, the authors develop a robust strategy for para-C–H arylation of arenes with a range of (het)aryl iodides, including bioactive molecules.