International Journal of General Medicine (Sep 2021)

Expression, Clinical Significance, and Prospective Pathway Signaling of miR-501-3p in Ovarian Cancer Based on Database and Informatics Analysis

  • Chen B,
  • Jin X,
  • Wang H,
  • Zhou Q,
  • Li G,
  • Lu X

Journal volume & issue
Vol. Volume 14
pp. 5193 – 5201

Abstract

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Buze Chen,1,2,* Xin Jin,3,* Haihong Wang,1 Qingmei Zhou,1 Guilin Li,3 Xiaoyuan Lu1 1Department of Gynecology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221000, People’s Republic of China; 2Xuzhou Medical University, Xuzhou, Jiangsu, 221000, People’s Republic of China; 3Department of Gynecology, Maternal and Child Health Care Hospital Affiliated to Xuzhou Medical University, Xuzhou, Jiangsu, 221000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoyuan LuDepartment of Gynecology, The Affiliated Hospital of Xuzhou Medical University, No. 99 West Huaihai Road, Quanshan District, Xuzhou, 221000, Jiangsu, People’s Republic of ChinaTel +86-180 52268119Email [email protected] LiDepartment of Gynecology, Maternal and Child Health Care Hospital Affiliated to Xuzhou Medical University, No. 46 Heping Road, Yunlong District, Xuzhou, Jiangsu, 221000, People’s Republic of ChinaTel +86-18936372957Email [email protected]: The present study aims to explore the expression, clinical significance, and prospective pathway signaling of miR-501-3p in ovarian cancer (OC) based on database and informatics analysis.Methods: Kruskal–Wallis test, Wilcoxon sign-rank test, and logistic regression were used to evaluate the relationship between clinical features and miR-501-3p expression. Kaplan–Meier survival curve analysis was used to explore the relationship between miR-501-3p expression and the prognosis of OC patients. The miRNA targets were obtained from databases TargetScan, miRanda, TarBase, miRTarBase, miR2Disease, miRecords, and miRWalk. GO and KEGG analyses were used to analyze the significant involvement of miR-501-3p target genes in function.Results: The low miR-501-3p expression in OC was significantly associated with histologic grade (P=0.015). Low miR-501-3p expression predicted a poorer overall survival (HR: 0.77; 95% CI: 0.61– 0.96; P=0.02) and disease-specific survival (HR: 0.77; 95% CI: 0.61– 0.99; P=0.038). GO and KEGG analyses demonstrated that miR-501-3p might participate in the development of OC by pathways including one carbon pool by folate, protein digestion and absorption, cell cycle, kaposi sarcoma-associated herpesvirus infection, and viral carcinogenesis.Conclusions: Low miR-501-3p expression is significantly associated with poor survival in OC patients. It may be a promising prognostic biomarker for OC patients.Keywords: microRNA-501-3p, ovarian cancer, prognosis, the cancer genome atlas, gene expression

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