The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury

Liyuan Zhu; Chuansheng Xu; Xingyu Huo; Huifeng Hao; Qing Wan; Hong Chen; Xu Zhang; Richard M. Breyer; Yu Huang; Xuetao Cao; De-Pei Liu; Garret A. FitzGerald; Miao Wang

doi:10.1038/s41467-019-09492-4

Nature Communications (Apr 2019)

The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury

Liyuan Zhu,
Chuansheng Xu,
Xingyu Huo,
Huifeng Hao,
Qing Wan,
Hong Chen,
Xu Zhang,
Richard M. Breyer,
Yu Huang,
Xuetao Cao,
De-Pei Liu,
Garret A. FitzGerald,
Miao Wang

Affiliations

Liyuan Zhu: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College
Chuansheng Xu: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College
Xingyu Huo: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College
Huifeng Hao: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College
Qing Wan: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College
Hong Chen: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College
Xu Zhang: Tianjin Key Laboratory of Metabolic Diseases and Department of Physiology, Tianjin Medical University
Richard M. Breyer: Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center
Yu Huang: Institute of Vascular Medicine and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Xuetao Cao: Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College
De-Pei Liu: Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College
Garret A. FitzGerald: Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania
Miao Wang: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College

DOI: https://doi.org/10.1038/s41467-019-09492-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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The use of nonsteroidal anti-inflammatory drugs inhibiting COX-1/2 is associated with an increased risk of heart failure. Here the authors show that mPGES-1, a therapeutic target downstream of COX enzymes, protects from cardiac ischemia/reperfusion injury, limiting leukocyte-endothelial interactions and preserving microvascular perfusion partly via the endothelial EP4 receptor.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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